Our Research

Our research seeks to understand how cells maintain the integrity of their genome.  We primarily use the budding yeast Saccharomyces cerevisiae as a model system for studying DNA Mismatch Repair and the pathways that prevent genome rearrangements.  We also actively apply insights from our S. cerevisiae studies to understanding how genome stability is dysregulated in many cancers and whether cancer therapies can be developed that target genome instability.
Latest Publications
FEN1 endonuclease as a therapeutic target for human cancers with defects in homologous recombination
Proceedings of the National Academy of Sciences, U S A  2020 Aug 11;117(32);19415-19424
Mechanisms underlying genome instability mediated by formation of foldback inversions in Saccharomyces cerevisiae
Elife 2020 Aug 7;9:e58223
Essential Saccharomyces cerevisiae genome instability suppressing genes identify potential human tumor suppressors
Proceedings of the National Academy of Sciences U S A. 2019 Aug 27;116(35):17377-17382.
The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
Journal of Biological Chemistry. 2018 Nov 23;293(47):18055-18070.
The Swr1 chromatin-remodeling complex prevents genome instability induced by replication fork progression defects
Nature Communications. 2018 Sep 11;9(1):3680
Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners
Nature Structural & Molecular Biology 2018 Aug;25(8):650-659